Influence of glycodelin on morphofunctional state of secondary immune organs in experimental model of allogeneic transplantation

Glycodelin (PP14, PAEP, alpha-2-microglobulin, dimeric glycoprotein with a molecular weight of 42 to 56 kDa) is marker reproductive tissue receptivity. Immunoregulatory potential glycodelin allows us consider it among key factors that promote maternal immune tolerance the developing embryo. In general, has prospects for use in biomedicine as biopharmaceutical treat post-transplant complications. This work aimed study effect on morpho-functional state secondary organs response course vivo experiment during allogeneic transplantation bone marrow cell suspension Wistar rats. The was performed white male rats aged 2-3 months (body mass, 250 g). animals were kept at Perm State National Research University animal clinic under GOST 33216-2014 “Rules working laboratory rodents and rabbits”. sacrificed 3rd, 7th, 14th, 21st days according international rules experimental animals. control group, (n = 6) injected once camptothecin-treated cells; 12) cells combination administered 4 times.We used recombinant (MyBioSource, Germany), which concentration corresponding pregnancy (0.75 μg/mL). Intraperitoneal injection simultaneously over terms (21 days) showed caused hyperplasia spleen lymph nodes. functional zones organs, proliferation differentiation developed. Injection early stages (3-7 an increase proliferative processes both T- B-dependent immunity. Moreover, there no signs inflammation apoptotic death organs. Since 14th day experiment, eosinophilic infiltration evident, being indirect positive sign transplanted cells. By end study, dominated Thus, stabilizes promotes emergence new generation, thus supporting host transplant. Apparently, can participate development adaptive mechanism system.